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    Bioinformatics2go

    What's New

    Recent papers:

    Daniel S Standage, Tim Lai & Volker P Brendel (2022) iLoci: Robust evaluation of genome content and organization for provisional and mature genome assemblies. Nucleic Acids Research Genomics and Bioinformatics 4, Issue 1, March 2022, lqac013, https://doi.org/10.1093/nargab/lqac013 [PubMed ID: 35211671] [online article] [PDF]

    Morandin, C., Brendel, V.P., Sundström, L.; Helanterä, H. & Mikheyev, A. (2019) Changes in gene DNA methylation and expression networks accompany caste specialization and age-related physiological changes in a social insect methylation. Molecular Ecology, 28, 1975-1993. [PubMed ID: 30809873] [online article] [PDF]

    The future of computational genomics:

      Brendel, V.P. (2018) From small RNA discoveries to a new paradigm in computational genomics? New Phytol. 220, 659-660. [PubMed ID: 30324739] [online article] [PDF]


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    Bioinformatics2go

    PairwiseStatSig


    Description: The PairwiseStatSig program estimates the pairwise statistical significance of a pairwise local alignment of two protein sequences independent of any database using censored Maximum Likelihood Fitting. Citation: Agrawal, A., Brendel, V. & Huang, X. (2008) Pairwise statistical significance versus database statistical significance for local alignment of protein sequences. In I.I. Măndoiu, R. Sunderraman & A.Z. Zelikovsky (eds.), 2008 International Symposium on Bioinformatics Research and Applications, May 6-9, 2008, Georgia State University, Atlanta GA, U.S.A.. Lecture Notes in Bioinformatics 4983, 50-61. [online abstract]; Agrawal, A., Brendel, V. & Huang, X. (2008) Pairwise statistical signifiance and empirical determination of effective gap opening penalties for protein local sequence alignment. Int. J. of Computational Biol. and Drug Design, 1(4), 347-367; to appear. Download: Download PairwiseStatSig